abstract：:We have investigated the mode of cardiovascular action of the stimulant methylhexaneamine (MHA) in terms of direct or indirect adrenergic actions in anaesthetised rats. Male and female rats were anaesthetised with pentobarbitone and pressor (changes in diastolic blood pressure) and cardioaccelerator responses to MHA w...

journal_title：European journal of pharmacology

authors： Alsufyani HA,Docherty JR

更新日期：2019-01-15 00:00:00

abstract：:Resveratrol reportedly promotes the improvement of cardiac dysfunction and other cardiovascular diseases. Studies demonstrate resveratrol exhibits a set of benefits, including anti-oxidative property, anti-apoptosis and anti-inflammation. However, the molecular mediators of resveratrol-induced cardiac benefits are sti...

journal_title：European journal of pharmacology

authors： Lu Y,Lu X,Wang L,Yang W

更新日期：2019-01-15 00:00:00

abstract：:The peroxisome proliferator-activated receptor-α (PPAR-α) controls the lipid and glucose metabolism and also affects inflammation, cell proliferation and apoptosis during cardiovascular disease. Raspberry ketone (RK) is a red raspberry (Rubusidaeus, Family-Rosaceae) plant constituent, which activates PPAR-α. This stud...

journal_title：European journal of pharmacology

authors： Khan V,Sharma S,Bhandari U,Sharma N,Rishi V,Haque SE

更新日期：2019-01-05 00:00:00

abstract：:COPD is a chronic lung disease characterized by persistent respiratory symptoms and airflow limitation due to airway and/or alveolar abnormalities. Furthermore, COPD is often characterized by extrapulmonary manifestations and comorbidities worsening COPD progression and quality of life. A neglected comorbidity in COPD...

journal_title：European journal of pharmacology

authors： Pelgrim CE,Peterson JD,Gosker HR,Schols AMWJ,van Helvoort A,Garssen J,Folkerts G,Kraneveld AD

更新日期：2019-01-05 00:00:00

abstract：:Annexin A1 (ANXA1)-formyl peptide receptor (Fpr) system is potent effective mediators in the control of the inflammatory response. In this study, we evaluate the potential involvement of the Fpr family in the protective effect of the mimetic peptide of ANXA1 (ANXA12-26) using an experimental allergic conjunctivitis (A...

journal_title：European journal of pharmacology

authors： Marmorato MP,Gimenes AD,Andrade FEC,Oliani SM,Gil CD

更新日期：2019-01-05 00:00:00

abstract：:Growing evidence supports involvement of low-affinity/high-capacity organic cation transporters (OCTs) and plasma membrane monoamine transporter (PMAT) in regulating clearance of monoamines. Currently decynium-22 (D22) is the best pharmacological tool to study these transporters, however it does not readily discrimina...

journal_title：European journal of pharmacology

authors： Fraser-Spears R,Krause-Heuer AM,Basiouny M,Mayer FP,Manishimwe R,Wyatt NA,Dobrowolski JC,Roberts MP,Greguric I,Kumar N,Koek W,Sitte HH,Callaghan PD,Fraser BH,Daws LC

更新日期：2019-01-05 00:00:00

abstract：:Receptor for advanced glycation end-products (RAGE) is involved in the pathogenesis of diabetic nephropathy. FPS-ZM1, a selective RAGE inhibitor, in combination with valsartan were investigated for their protective potentials on the renal markers of tubular injury in streptozotocin-induced diabetic rats. Rats were ass...

journal_title：European journal of pharmacology

authors： Sanajou D,Ghorbani Haghjo A,Argani H,Roshangar L,Rashtchizadeh N,Ahmad SNS,Ashrafi-Jigheh Z,Bahrambeigi S,Asiaee F,Rashedi J,Aslani S

更新日期：2019-01-05 00:00:00

abstract：:Jolkinolide B (JB), which is isolated from the dried root of Euphorbia fischeriana Steud., has been reported to possess various therapeutic effects, such as treatment of edema and abdominal distention and protection against acute lung injury, and it has also been reported to have anti-inflammatory even antitumor prope...

journal_title：European journal of pharmacology

authors： Yan Y,Wang Y,Wang X,Liu D,Wu X,Xu C,Chen C,Li Z

更新日期：2019-01-05 00:00:00

abstract：:Icariin is a major active component of the traditional herb Epimedium, also known as Horny Goat Weed. It has been extensively studied throughout the past several years and is known to exert anti-oxidative, anti-neuroinflammatory, and anti-apoptotic effects. It is now being considered as a potential therapeutic agent f...

journal_title：European journal of pharmacology

authors： Jin J,Wang H,Hua X,Chen D,Huang C,Chen Z

更新日期：2019-01-05 00:00:00

abstract：:The correlation between the Phosphoinositide 3-kinase (PI3K) axis and crucial mechanisms involved in the maintenance of the neoplastic nature of multiple myeloma (MM) has recently evolved a general agreement that PI3K inhibition-based therapies could construct an exciting perspective for the future treatment strategie...

journal_title：European journal of pharmacology

authors： Safaroghli-Azar A,Bashash D,Kazemi A,Pourbagheri-Sigaroodi A,Momeny M

更新日期：2019-01-05 00:00:00

abstract：:The loss of cholinergic neurons has been a major issue in researches on Alzheimer's disease (AD) for about 40 years. Therefore, the scopolamine model of amnesia has been widely used in AD researches. Recently, it was reported that the early stage amnesia of AD is related to memory retrieval deficit. Curcumin, as the m...

journal_title：European journal of pharmacology

authors： SoukhakLari R,Moezi L,Pirsalami F,Ashjazadeh N,Moosavi M

更新日期：2018-12-15 00:00:00

abstract：:Cholangiocarcinoma (CCA) is one of the most serious of all cancers and a major public health problem. CCA is an extremely invasive cancer, and the survival rate for CCA patients is only 24 months after diagnosis. Although surgery and chemotherapy can extend the survival rate to 5 years, < 20-40% of CCA patients will s...

journal_title：European journal of pharmacology

authors： Lee MY,Li YZ,Huang KJ,Huang HC,Lin CY,Lee YR

更新日期：2018-11-15 00:00:00

abstract：:Hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor stabilizes hypoxia inducible factor alpha, which increases erythropoietin (EPO) expression via the hypoxia response element. Therefore, PHDs inhibitors have been developed as novel therapeutic agents for anemia. Here, we characterize the in vitro and in viv...

journal_title：European journal of pharmacology

authors： Kato S,Takayama N,Takano H,Koretsune H,Koizumi C,Kunioka EI,Uchida S,Takahashi T,Yamamoto K

更新日期：2018-11-05 00:00:00

abstract：:Cutaneous arteries show enhanced contraction in response to cooling, which is suggested to be mediated via α2C-adrenoceptors. We have previously shown that α1-adrenoceptors are also involved in the enhanced contraction in cooling conditions. In the present study, we aimed to identify the α1-adrenoceptor subtype involv...

journal_title：European journal of pharmacology

authors： Ishida H,Saito SY,Ishikawa T

更新日期：2018-11-05 00:00:00

abstract：:Donor-specific antibodies (DSA) are a major risk factor for antibody-mediated rejection (ABMR) in solid organ transplantation, and ABMR remains a medical challenge. Therefore, effective anti-ABMR therapies are needed to improve overall graft survival. Cathepsin S (Cat S) is an essential protease for antigen peptide lo...

journal_title：European journal of pharmacology

authors： Kubo K,Kawato Y,Nakamura K,Nakajima Y,Nakagawa TY,Hanaoka K,Oshima S,Fukahori H,Inami M,Morokata T,Higashi Y

更新日期：2018-11-05 00:00:00

abstract：:Depression is very common in asthmatic patients and may increases risk for morbidity and mortality. The present work aimed to investigate the protective effect of fluoxetine, on behavioral and biochemical changes, associated with ovalbumin (OVA) - induced bronchial asthma and depression in rats. Rats were sensitized w...

journal_title：European journal of pharmacology

authors： Sherkawy MM,Abo-Youssef AM,Salama AAA,Ismaiel IE

更新日期：2018-10-15 00:00:00

abstract：:Obese mice display overactive bladder (OAB) associated with impaired urethra smooth muscle (USM) function. In this study, we evaluated the role of the adipose tissue surrounding the urethra and prostate in obese mice (here referred as periprostatic adipose tissue; PPAT) to the USM dysfunction. Male C57BL6/JUnib mice f...

journal_title：European journal of pharmacology

authors： Alexandre EC,Calmasini FB,Sponton ACDS,de Oliveira MG,André DM,Silva FH,Delbin MA,Mónica FZ,Antunes E

更新日期：2018-10-05 00:00:00

abstract：:Early philosophers and psychologists defined and began to describe attention. Beginning in the 1950's, numerous models of attention were developed. This corresponded with an increased understanding of pharmacological approaches to manipulate neurotransmitter systems. The present review focuses on the knowledge that ha...

journal_title：European journal of pharmacology

authors： Burk JA,Blumenthal SA,Maness EB

更新日期：2018-09-15 00:00:00

abstract：:Chronic restraint stress (CRS) is known to cause metabolic and neurological complications in a number of ways. Prolonged exposure to stress evident by increased corticosterone level led to impaired altered insulin signaling and oxidative stress in mice, in the present study. Impaired insulin signaling or insulin resis...

journal_title：European journal of pharmacology

authors： Mourya A,Akhtar A,Ahuja S,Sah SP,Kumar A

更新日期：2018-09-15 00:00:00

abstract：:Pulmonary hypertension (PH) is a disease with a developmental origin characterized by obstructive vascular remodelling that is partially due to excessive pulmonary arterial smooth muscle cells (PASMCs) proliferation. Paeonol has important effects on vascular cell proliferation, migration, and inflammation, but researc...

journal_title：European journal of pharmacology

authors： Zhang L,Ma C,Gu R,Zhang M,Wang X,Yang L,Liu Y,Zhou Y,He S,Zhu D

更新日期：2018-09-05 00:00:00

abstract：:This study examined the potential of the selective extra-synaptic α5-GABAA receptor inhibitor S44819 (Egis-13529) to improve cognitive performance in preclinical models of vascular cognitive impairment (VCI). Chronic hypoperfusion of the brain in mice was induced by permanent occlusion of the right common carotid arte...

journal_title：European journal of pharmacology

authors： Gacsályi I,Móricz K,Gigler G,Megyeri K,Machado P,Antoni FA

更新日期：2018-09-05 00:00:00

abstract：:A few decades ago, cardiac muscle was discovered to possess signalling pathways that, when activated, protect the myocardium against the damage induced by ischaemia-reperfusion. The ability of cardiac muscle to protect itself against injury has been termed 'cardioprotection'. Many compounds and procedures can trigger ...

journal_title：European journal of pharmacology

authors： Jovanović A

更新日期：2018-08-15 00:00:00

abstract：:Ischemia-reperfusion injury(IRI), described as tissue damage caused by reversible ischemic injury or hypoxia prior to the blood supply restoration, is a common pathological phenomenon. In recent study, a hypoxia-reoxygenation (H/R) in the presence or absence of propofol posthypoxia treatment (P-PostH) cell model was b...

journal_title：European journal of pharmacology

authors： Zhang L,Ruan Z,Liang J,Du Y,Lu Z,Feng D,Cai S,Zhang X,Cai W,Hu Z

更新日期：2018-08-15 00:00:00

abstract：:Notoginsenoside R1, a unique constituent from the root of Panax notoginseng, exerts anti-inflammatory, anti-oxidative and anti-apoptotic properties. The purpose of this study was to assess the contribution of the anti-inflammatory effects of R1 to the amelioration of isoproterenol (ISO)-induced hypertrophied hearts of...

journal_title：European journal of pharmacology

authors： Xiao J,Zhu T,Yin YZ,Sun B

更新日期：2018-08-15 00:00:00

abstract：:Patients with somatic mutations of epigenetic regulators are characterized by aberrant chromatin modification patterns. Recent mechanistic studies pairing chemical tool compounds and deep-sequencing technology have greatly broadened our understanding of epigenetic regulation in glioma progression and underpinned alter...

journal_title：European journal of pharmacology

authors： Chen YH,Zeng WJ,Wen ZP,Cheng Q,Chen XP

更新日期：2018-08-15 00:00:00

abstract：:The present study examines the effect of three adenosine receptor antagonists on tremulous jaw movements (TJMs), an animal model of tremor. Forty-five rats were pre-treated with one adenosine antagonist: caffeine (0.0, 5.0, or 10.0 mg/kg; non-selective adenosine receptor antagonist), 8-cyclopentyltheophylline (CPT; 0....

journal_title：European journal of pharmacology

authors： Johnson JA,Montgomery AP,Starr ER,Ludwig J,Trevitt J

更新日期：2018-08-15 00:00:00

abstract：:Factor Xa inhibitors reduce stroke in patients with atrial fibrillation. Pulmonary veins (PVs) and the sinoatrial node (SAN) are crucial for genesis of atrial fibrillation. However, the electrophysiological effects of factor Xa inhibitors (edoxaban and rivaroxaban) on PVs and the SAN remain unclear. Conventional micro...

journal_title：European journal of pharmacology

authors： Chang CJ,Cheng CC,Chen YC,Higa S,Huang JH,Chen SA,Chen YJ

更新日期：2018-08-15 00:00:00

abstract：:Stem cells have high potential for cell therapy in regenerative medicine. We previously isolated stem cell types from human amniotic fluid, derived from prenatal amniocentesis. One type, characterized by a fast doubling time, was designated as fast human amniotic stem cells (fHASCs). These cells exhibited high differe...

journal_title：European journal of pharmacology

authors： Romani R,Manni G,Donati C,Pirisinu I,Bernacchioni C,Gargaro M,Pirro M,Calvitti M,Bagaglia F,Sahebkar A,Clerici G,Matino D,Pomili G,Di Renzo GC,Talesa VN,Puccetti P,Fallarino F

更新日期：2018-08-15 00:00:00

abstract：:Cancer is the second leading cause of mortality worldwide. Therapeutic approach to cancer is a multi-faceted one, whereby many cellular/enzymatic pathways have been discovered as important drug targets for the treatment of cancer. A major disadvantage of most of the currently available anticancer drugs is their non-se...

journal_title：European journal of pharmacology

authors： Iqbal J,Ejaz SA,Saeed A,Al-Rashida M

更新日期：2018-08-05 00:00:00

abstract：:Lipopolysaccharide (LPS) is one of the many reasons that can cause myocardial injury. Our previous works have demonstrated that 14-3-3γ could protect myocardium against LPS-induced injury. Tetramethylpyrazine (TMP), an alkaloid found in Chinese herbs, exerts myocardial protection in many ways with multiple targets. We...

journal_title：European journal of pharmacology

authors： Huang B,You J,Qiao Y,Wu Z,Liu D,Yin D,He H,He M

更新日期：2018-08-05 00:00:00

abstract：:Dexmedetomidine (DMED) is a potent and highly selective α2-adrenergic receptor agonist and is widely used for short-term sedation. However, the mechanism of DMED-induced sedation has not been deciphered. In the present study, we investigated the mechanism of Gαi and Gβγ subunits on DMED-induced sedation. An ED50 of DM...

journal_title：European journal of pharmacology

authors： Liu M,Yang Y,Tan B,Li Y,Zhou P,Su R

更新日期：2018-07-15 00:00:00

abstract：:Preeclampsia is reported in pregnant women around the world and often causes maternal/fetal mortality and morbidity. In the current study, we assessed the efficacy of celastrol on a rat preeclampsia model induced by Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME). Pregnant rats were administered L-NAME to esta...

journal_title：European journal of pharmacology

authors： Xiao S,Zhang M,He Z,Wang D

更新日期：2018-07-05 00:00:00

abstract：:Long-term treatment with antipsychotic drugs in patients with schizophrenia can lead to dopamine supersensitivity psychosis. It is reported that repeated administration of haloperidol caused dopamine supersensitivity in rats. Blonanserin is an atypical antipsychotic drug with high affinity for dopamine D2, D3 and sero...

journal_title：European journal of pharmacology

authors： Hashimoto T,Baba S,Ikeda H,Oda Y,Hashimoto K,Shimizu I

更新日期：2018-07-05 00:00:00

abstract：:Antidepressant drugs are currently one of the most prescribed medications. In addition to treatment resistance and side effects of antidepressants, their clinical use is further complicated by antidepressant discontinuation syndrome (ADS). ADS is a common problem in patients following the interruption, dose reduction,...

journal_title：European journal of pharmacology

authors： Zabegalov KN,Kolesnikova TO,Khatsko SL,Volgin AD,Yakovlev OA,Amstislavskaya TG,Alekseeva PA,Meshalkina DA,Friend AJ,Bao W,Demin KA,Gainetdinov RR,Kalueff AV

更新日期：2018-06-15 00:00:00

abstract：:The main purpose of this study was to compare in vitro pharmacological properties of human αCGRP (CGRP) and a recently discovered metabolically stable CGRP analogue, SAX, in isolated rat and human artery segments. In rat, CGRP and SAX induced similar vasodilatory responses in isolated mesenteric artery with the potenc...

journal_title：European journal of pharmacology

authors： Sheykhzade M,Abdolalizadeh B,Koole C,Pickering DS,Dreisig K,Johansson SE,Abboud BK,Dreier R,Berg JO,Jeppesen JL,Sexton PM,Edvinsson L,Wootten D,Sams A

更新日期：2018-06-15 00:00:00

abstract：:This study investigates the effect and the underlying mechanism of 2',3-dihydroxy-5-methoxybiphenyl (RIR-2), a lignan extracted from the roots of Rhaphiolepis indica (L.) Lindl. ex Ker var. tashiroi Hayata ex Matsum. & Hayata (Rosaceae), on N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-induced respiratory burst...

journal_title：European journal of pharmacology

authors： Liao HR,Chen IS,Liu FC,Lin SZ,Tseng CP

更新日期：2018-06-15 00:00:00

abstract：:Evidence has shown that downstream signaling by mu opioid receptor (MOR) agonists that recruit β-arrestin2 may lead to the development of tolerance. Also, it has been suggested that opioid receptor desensitization and cyclic AMP overshoot contributes to the development of tolerance and occurrence of withdrawal, respec...

journal_title：European journal of pharmacology

authors： Obeng S,Yuan Y,Jali A,Selley DE,Zhang Y

更新日期：2018-05-15 00:00:00

abstract：:Pentoxifylline (PTX), a non-specific inhibitor of cAMP phosphodiesterases, is commonly used for treatment of peripheral vascular disorders although its direct action on endothelial cells is not well described. The aim of this study was to determine the influence of PTX on tubule formation and mRNA expression for angio...

journal_title：European journal of pharmacology

authors： Niderla-Bielińska J,Bartkowiak K,Ciszek B,Czajkowski E,Jankowska-Steifer E,Krejner A,Ratajska A

更新日期：2018-05-15 00:00:00

abstract：:In the present study, the functional properties of α7 nicotinic acetylcholine receptors (α7 nAChRs) and N-methyl-D-aspartate receptors (NMDARs) endogenously expressed in SH-SY5Y human neuroblastoma cells were characterized in an extracellular-signal regulated kinase (ERK) phosphorylation assay. Both choline and N-meth...

journal_title：European journal of pharmacology

authors： Elnagar MR,Walls AB,Helal GK,Hamada FM,Thomsen MS,Jensen AA

更新日期：2018-05-05 00:00:00

abstract：:The pharmacological profile of DSP-6952, a novel 5-HT4 receptor partial agonist, was investigated to evaluate the potential use for GI disorders, and to compare its effects in some GI dysfunction models with those of clinically efficacious prokinetic agents. DSP-6952 enhanced gastric motility and caused colonic giant ...

journal_title：European journal of pharmacology

authors： Mine Y,Itakura T,Oku S,Asada R,Shimizu I

更新日期：2018-05-05 00:00:00